MASTER'S

RESEARCH PROJECT

CREATION OF AN EDUCATIONAL 3D BIOMEDICAL ANIMATION & CINEMATIC DESIGN

SEE MORE STUFF ON PC

felixvis.com

Written, directed, and animated by Felix Donghwi Son ©2019

Supervised by Jodie Jenkinson (ScienceVis lab), 

instructed by Marc Dryer, Gaël McGill, and Susan Keen

RESEARCH
BACKGROUND
 
 

BEHIND STORY

The ability to move is a key aspect of evolution for communication and survival by living organisms. Most motile cells rely on a dynamic system of actin skeleton for locomotion.

Actin is the most plentiful and highly conserved protein in most eukaryotic cells (Dominguez & Holmes, 2011). It participates in more protein-protein interactions than any other known proteins (Dominguez & Holmes, 2011). This property makes actin a crucial player in a large range of cellular processes, ranging from the maintenance of cell morphology to the establishment of polarity, especially in cell motility (Dominguez & Holmes, 2011).

 

The machinery of the cell shape changes and motility rely on the continuous assembly and disassembly of different architectures of actin skeleton (Blanchoin et al., 2014). These complex processes are controlled by the dynamic interaction of actin and actin-binding proteins in order to achieve cell motility (Svitkina, 2018).

COMMUNICATION GAP

Though It is important to understand these concepts for those studying cell biology, undergraduate cell biology students have difficulties in gaining a comprehensive understanding of actin structures and the processes of cell movement due to the complexity of the topic.

- For example, this biological concept involves hundreds of Actin-Binding Proteins (ABP), as well as other intracellular and extracellular factors (Blanchoin et al., 2014).  There are many stages involved such as assembly, disassembly, and remolding of actin structures.

-  Many of the challenges in molecular life science education are linked to the interdisciplinarity of the field, bridging cell biology, chemistry, and mathematics. This requires a much more integrated understanding of complex biological concepts (Jenkinson, 2012).   Due to the lecture-based nature of the educational environment and the limitation of existing supplementary visual resources, the students’ understanding on cell movement is limited.

PRIMARY AUDIENCE

Undergraduate cell biology students.

PRIMARY GOALS

This research primarily attempts to bridge the knowledge gap in undergraduate cell biology students’ understanding of key biological concepts.

01

The fundamental characteristics of actin cytoskeleton in cell movement.

02

The underlying principles, and mechanism regulating the dynamics of actin architecture .

For my master’s research project, I propose

to develop an educational 3D animation

on the role of actin in cell motility

as a supplementary visual learning resource

for undergraduate cell biology students.

2018 July

Research Proposal

COMMITTEE

Supervisor

Jodie Jenkinson

MScBMC, PhD, FAMI

Director of MScBMC

& Associate professor

University of Toronto

2nd Voting Member

Marc Dryer

MSc, MScBMC

Associate Chair of Biology 

& Associate professor

University of Toronto

Visualization Expert  

Gaël McGill

PhD

Director of Molecular Visualization

Founder & CEO, Digizyme Inc.

Havard Medical School

Content Expert

Susan L. Keen

MSc, PhD

Professor of Teaching

Associate Dean (2012 -2018)

University of California Davis

 

PRE-PRODUCTION

- Identify Project Scope

- Content Research

- Story development

ANIMATICS

- Cinematic story design

- Identify Potential Problems

   in linear storytelling

04

05

SEQUENCE

BREAKDOWN

- Identify Sequence #

- List of Visual Elements

02

SCRIPT

- Literature Review

- Existing Media Audit

- Need Assessment

PROPOSAL

01

- Idea sketches

- Conceptualization 

- Clarify Storytelling

STORYBOARD

03

 

PRODUCTION &

POST-PRODUCTION

Example 01

Rapid elongation of

parallel Actin bundles

regulated by elongation factor, formin

Example 02

Complex network of

cytoskeletal fibers with Kinesin,

a motor protein on microtubule

RENDERING

- Autodesk Maya

     (Solid Arnold)

09

MODELING

& RIGGING

- Autodesk Maya

- Pixologic Zbrush

- UCSF Chimera

06

SCENE DESIGN

- Autodesk Maya

07

PLAYBLAST

- Autodesk Maya

08

COMPOSITING

- Adobe After effects

- Adobe Illustrator

- Adobe Premiere pro

10

Pre-production

Concept Sketches

Tissue environment

Crawling lymphocyte

Contractile Stress Fibers

Title shot

Cytoskeletal Network

Actin polymerization

Actin Branching

Mesh-like actin network

Parallel actin bundle

Post-production

Final Images

 

QUICK REVIEW

ROUGH VS FINAL

Find interesting differences and similarities between
pre-production concept sketches and post-production final images
Let's collaborate!
FELIXVIS WHITE YELLOW.png

©

2020 felixvis. All Rights Reserved.
Latest on Instragram
 @felixvis
Designed by Felixvis
  • Instagram - Grey Circle
  • LinkedIn - Grey Circle
  • Facebook - Grey Circle
  • Vimeo - Grey Circle