Biomedical Data Visualization

Quantification of Cellular

Organelle Size

 

Designed for undergraduate students, this illustration visualizes the quantification of organelles of a typical mammalian cell.

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STORY

Scale at the sub-cellular level is often misrepresented in textbook illustrations, which may lead to students developing misconceptions about the structure of cells. Furthermore, information about the scale and properties of organelles is fragmented and difficult to find. This illustration aims to provide students with a more complete understanding of the structure and composition of a typical mammalian cell.

 

To achieve this goal, I built the 3D model of the cell and organelles based on proportions and dimensions as published in Cell Biology by the Numbers (Milo and Phillips, 2015), and recent articles. A graphical legend and colour-coding scheme were designed to link the central visual with the scientific data, and a simple black background was incorporated to draw attention on the data visualization.

DESCRIPTION

Year

April.2018

Course

BMC Technology 2: 

Data and Information Visualization

Client

Andrea Gauthier

Audience

Undergraduate Students

Format

Print, Poster 

Medium

Pixologic Zbrush
Maxon Cinema4D
Adobe Photoshop
Adobe Illustrator

01

Preliminary

Sketches

PROCESS WORK

Production

03

02

Design

REFERENCE

Frey, Terrence G., Guy A. Perkins, and Mark H. Ellisman. "Electron tomography of membrane-bound cellular organelles." Annu. Rev. Biophys. Biomol. Struct. 35 (2006): 199-224.

Sengupta, Debrup, and Adam D. Linstedt. "Control of organelle size: the Golgi complex." Annual review of cell and developmental biology 27 (2011): 57-77.

Gurel, Pinar S., Anna L. Hatch, and Henry N. Higgs. "Connecting the cytoskeleton to the endoplasmic reticulum and Golgi." Current biology 24, no. 14 (2014): R660-R672.

Chan, Yee-Hung M., and Wallace F. Marshall. "Scaling properties of cell and organelle size." Organogenesis 6, no. 2 (2010): 88-96.

Chan, Yee-Hung M., and Wallace F. Marshall. "How cells know the size of their organelles." Science 337, no. 6099 (2012): 1186-1189.

Reber, Simone, and Nathan W. Goehring. "Intracellular scaling mechanisms." Cold Spring Harbor perspectives in biology 7, no. 12 (2015): a019067.

Levy, Daniel L., and Rebecca Heald. "Mechanisms of intracellular scaling." Annual review of cell and developmental biology 28 (2012): 113-135.

Edens, Lisa J., Karen H. White, Predrag Jevtic, Xiaoyang Li, and Daniel L. Levy. "Nuclear size regulation: from single cells to development and disease." Trends in cell biology 23, no. 4 (2013): 151-159.

Milo, Ron, and Rob Phillips. Cell biology by the numbers. Garland Science, 2015.

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