The goal for this project was to create a conceptual illustration demonstrating etiology, pathogenesis, and clinical consequences of a disease. A major challenge was finding a two-page layout that could effectively depict those concepts in a way that is easy to understand, anatomically accurate, and visually engaging.

On the first page, the anterior part of the left ventricle including right ventricular outflow tract is removed to effectively show the mitral valve. Etiology and pathogenesis are explained in three steps, using color-coded labels and vector elements for clear communication. On the second page, the mitral valve is visualized at a bigger scale with call outs to ensure effective connection between pathogenesis and clinical consequences.




Visual representation of processes in human pathology


Shelley Wall



John Wong

Gwan Hyun Yoon


Educated lay audience


Print, Magazine

two-page spread


ipad Procreate

Adobe Photoshop

Adobe Illustrator

McCarthy, K. P., Ring, L., & Rana, B. S. (2010). Anatomy of the mitral valve: understanding the mitral valve complex in mitral regurgitation. European Journal of echocardiography, 11(10), i3-i9.


Selzer, A., & Cohn, K. E. (1972). Natural history of mitral stenosis: a review. Circulation, 45(4), 878-890.


Roberts, S., Kosanke, S., Dunn, S. T., Jankelow, D., Duran, C. M., & Cunningham, M. W. (2001). Pathogenic mechanisms in rheumatic carditis: focus on valvular endothelium. The Journal of infectious diseases, 183(3), 507-511.


Gao, H., Qi, N., Feng, L., Ma, X., Danton, M., Berry, C., & Luo, X. (2017). Modelling mitral valvular dynamics–current trend and future directions. International journal for numerical methods in biomedical engineering, 33(10), e2858.


Bisno, A. L. (1991). Group A streptococcal infections and acute rheumatic fever. New England journal of medicine, 325(11), 783-793.


Drake, R., Vogl, A. W., & Mitchell, A. W. (2009). Gray's Anatomy for Students E-Book. Elsevier Health Sciences.


Schünke, M., Schulte, E., Schumacher, U., Ross, L. M., Lamperti, E. D., & Voll, M. (2010). Neck and Internal Organs (THIEME Atlas of Anatomy).


Netter, F. H. (2008). Netter-Atlas de anatomia humana. Elsevier Brasil.

Rheumatic valvulitis – Forgotten, but not gone


WiRED International -  Strep Throat to Rheumatic Heart Disease


khanacademymedicine - What is valvular heart disease?


Osmosis - Rheumatic fever & heart disease


Rheumatic heart disease: pathophysiology


PEIR Digital Library


Mark Pool, M.D. Rush University Medical Center