DNA-damaging agents are a cornerstone of cancer treatment. However, their effectiveness is limited by the DNA-damage response in cancer cells. ATR, a protein kinase, is a critical regulator of this DNA repair pathway and is a novel therapeutic target for drug design.

 

I created this two-page spread for a popular science magazine to illustrate the mechanism of action for VX-970, an ATR-inhibitor and cancer suppressor. I summarized ATR suppression into five steps showing the mechanism at both microscopic and molecular levels. A combination of colour-coding scheme, depth of field, and simplicity in background design were used to enhance communication clarity.

Year

July.2018

Course

Biomolecular Visualization

Client

Derek Ng

Audience

Educated lay audience

Format

Print, Magaine

two-page spread

Medium

UCSF Chimera

Maxon Cinema4D

Adobe Photoshop

Adobe Illustrator

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Stephen P. Bell (MIT / HHMI) 1b: Chromosomal DNA
Replication: Initiation of DNA Replication
https://www.youtube.com/watch?v=sxedBRA18Ro&t=616s

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Rao, Q., Liu, M., Tian, Y., Wu, Z., Hao, Y., Song, L., ... & Xu, Y. (2018).
Cryo-EM structure of human ATR-ATRIP complex. Cell research, 28(2),
143.

 

Hall, A. B., Newsome, D., Wang, Y., Boucher, D. M., Eustace, B., Gu, Y., ... &
Takemoto, D. (2014). Potentiation of tumor responses to DNA damaging
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Rao, Q., Liu, M., Tian, Y., Wu, Z., Hao, Y., Song, L., ... & Xu, Y. (2018).
Cryo-EM structure of human ATR-ATRIP complex. Cell research, 28(2),
143.

 

Lu, Y., Knapp, M., Crawford, K., Warne, R., Elling, R., Yan, K., ... &
Mamo, M. (2017). Rationally designed PI3Kα mutants to mimic ATR
and their use to understand binding specificity of ATR
inhibitors. Journal of molecular biology, 429(11), 1684-1704. 2.

 

Vendetti, F. P., Lau, A., Schamus, S., Conrads, T. P., O'Connor, M. J., &
Bakkenist, C. J. (2015). The orally active and bioavailable ATR kinase
inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to
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